Lee is famous for, amongst others, playing the title role in Singapore's Mediacorp Channel 5 television sitcom Police & Thief as Lee Tok Kong, Phua Chu Kang Pte Ltd as guest appearance Lee Kok Peng from season 5 until season 7 and in Mediacorp Channel 8 long series television drama Holland V as Su Hao. He also gained recognition for his work with Jack Neo and Henry Thia in films such as Money No Enough and Liang Po Po: The Movie and long-running comedy variety programme Comedy Nite (搞笑行动). He made his directorial debut in the comedy horror film The Ghosts Must Be Crazy.
Along with long-time colleague Christopher Lee, Mark Lee was awarded the coveted All Time Favourite Artiste award in the Star Awards 2010 and became the first host-cum-comedian to win the award as the previous winners were predominantly thespians. As such he will no longer be in the run for the Top 10 Most Popular Male Artistes awards in future Star Awards.
Although Lee was mostly known for playing comedic roles early in his career, he has also diversified into hosting and hosted various kinds of programmes, mainly infotainment, travelogue and DIY programmes. He co-hosted the popular home makeover programme Home Decor Survivor and the infotainment programme Behind Every Job with Bryan Wong, which won both a string of nominations in the hosting categories at the Star Awards. In 2012 he won his fourth Best Variety Host award for his popular show It's a Small World (season 2).
Lee was always given an on-screen name/surname of Ong or Huang, particularly in Jack Neo's movies, with the exception of Liang Po Po: The Movie, That One Not Enough and Ah Long Pte Ltd.
On 9 March 2017, Lee opened a production house King Kong Media Production with partner Yinson Marine Services, a Malaysian oil and gas company. He is now working on a film project for 2018.

Number 2
2025

Close Ur Kopitiam
2025

Wonderland
Loke
2024

Money No Enough 3
Ah Huang
2024

Geylang
Fatty
2023

The King Of Musang King
Jin Shui
2023

What! The Heist
2023

Reunion Dinner
Uncle
2022

The Diam Diam Era Too
Lim Ah Kun
2021

The Diam Diam Era
Lim Ah Kun
2020

Number 1
Chow Chee Beng
2020

How Are You?
Story Teller · (1 episode)
2019

Make It Big Big
2019

23:59: The Haunting Hour
Commando Leader
2018

Ramen Shop
Ah Wee
2018

Lee Chong Wei: Rise of the Legend
Lee Ah Chai
2018

Wonderful! Liang Xi Mei
Robert
2018

The Fortune Handbook
Huat God
2017

Long Long Time Ago 2
Lim Ah Kun
2016

Long Long Time Ago
Lim Ah Kun
2016

King of Mahjong
Wong Tin Ba
2015

Time is Money
Chu Zhong Tian
2015

A Fantastic Ghost Wedding
Master Wong
2014

Filial Party
Millionaire Liu
2014

Everybody's Business
Winston Lee
2013

Judgement Day
Du Jin De
2013

Taxi! Taxi!
Lee Ah Tau
2013

Greedy Ghost
Book Spirit
2012

Ghost Buddies
Hui
2012

Petaling Street Warriors
Shi DuYao
2011

23:59
Sergeant Kuah
2011

Twisted
Tan Sze Guan
2011

Homecoming
Chef Daniel Koh
2011

The Ghosts Must Be Crazy
Ah Hai
2011

Just Call Me Nobody
Fu Dong-Dang
2010

Being Human
Mai Wei/Max
2010
Carlsberg Lunar New Year Variety Show 2010
(5 episodes)
2010

Where Got Ghost?
Yang Baohuang
2009

Love Matters
Xiao Han
2009

Money Not Enough 2
Yang Bao Huang
2008

Ah Long Pte Ltd
Jojo Fang
2008

Just Follow Law
Gay #1
2007

One More Chance
Chin Wu Huang
2005

I Do, I Do
Loan shark
2005

The Best Bet
Huang
2004

Homerun
Kun's P.E. teacher
2003

I Not Stupid
Kidnapper
2002

One Leg Kicking
Handsome
2001

Eating Air
Lao Beng
1999

That One Not Enough
Zhu Guo Rong
1999

Liang Po Po: The Movie
Ah Beng
1999

Money No Enough
Ong
1998
NO GOOD!歐吉桑

Number 96
(1095 episodes)
1972