An English actress and writer, mainly in comedy. She is known for her roles in the Garth Marenghi series and as the lead and co-writer of the 2012 film Sightseers. She wrote, directed and starred in the 2016 black comedy Prevenge, whilst pregnant herself.
Lowe was born in Coventry, West Midlands, England. She attended Kenilworth School and graduated from King's College, Cambridge, where she studied classics. At university she became involved in theatre and comedy.
Lowe began her career in surreal experimental theatre shows including City Haunts, Snowbound and Progress in Flying Machine co-devising and performed along with colleagues such as Robert Webb and David Mitchell.
Lowe worked under the directorship of Paul King, who has since directed her in The Mighty Boosh and Garth Marenghi's Darkplace. She was cast in Garth Marenghi's Fright Knight alongside fellow Cambridge graduates Richard Ayoade and Matt Holness and they were nominated for the Perrier Award at the Edinburgh Fringe in 2000. In 2001, she won an award for performing in the sequel to Fright Knight, Garth Marenghi's Netherhead, at the Edinburgh Festival Fringe.
Her television credits include Channel 4's spoof horror comedy Garth Marenghi's Darkplace, Beth in the BBC comedy series My Life in Film, David Bowie in the BBC series Snuff Box, and a recurring role in Rob Brydon's Annually Retentive. She was part of the all-female comedy show Beehive along with Sarah Kendall, Barunka O'Shaughnessy and Clare Thomson which was aired on E4, and was a regular cast member of the CBBC show Horrible Histories during the second, third and fifth seasons. Her BBC Three pilot "LifeSpam: My Child Is French" was broadcast in 2009, and she co-wrote and starred in Channel 4's Orcadia. In February 2010, she appeared in and script-edited the pilot for a "sort-of-sketch-show" called Missing Scene.
She has also guest starred as Monkey in "The Priest and the Beast" episode of The Mighty Boosh, as Patricia in the "Fifty-Fifty" episode of The IT Crowd, a solicitor in the "Travel Writer" episode of Black Books, Madonna in an episode of Channel 4's Star Stories, and episodes of Little Britain, Come Fly with Me, Ruddy Hell! It's Harry and Paul, Beautiful People and This is Jinsy. She appeared in the music video for "Bastardo" by Charlotte Hatherley, directed by Edgar Wright.

Swede Caroline
Olga
2024

Partygate
Shelley Williams-Walker
2023

Greatest Days
Heather
2023

The Almond and the Seahorse
Cath
2022

God's Petting You
Therapist
2022

Eternal Beauty
Alice
2020

The Fight
Heather
2019

Wild Honey Pie!
Gerry
2018

The Ghoul
Kathleen
2017

Chubby Funny
Susan
2017

Prevenge
Ruth
2017

Ghosted
Rebecca
2016

Burn Burn Burn
Davina
2016

Stoner Express
Roxy
2016

Adult Life Skills
Alice
2016

Black Mountain Poets
Lisa
2016
Mosquito
2015

Aaaaaaaah!
Sitcom Eudora
2015

Night Feed
Young Mum
2015

Joseph's Reel
The Projectionist
2015

Electricity
Sylvia
2014

Paddington
Geographers' Guild Receptionist
2014

Girl Power
Alex
2014

Locke
Sister Margaret (voice)
2014
Pieces
Woman
2013

The World's End
Young Lady
2013

Sightseers
Tina
2012

Kill List
Radio Reporter
2011

This Christmastime
Val Hallah
2010

Brethren
Alice
2010
Dead Happy
Lucy the Grim Reaper
2010
Connections
Wife
2008

Out of Water
Maria Bootle
2007

Hot Fuzz
Tina
2007

Sticks & Balls
Kitty Litta
2007
Stiffy
Corpse
2005

Rogue Trooper
152 Days

The Extraordinary Miss Flower
Self
2025

Generation Terror
Herself
2024

Timestalker
Agnes
2024

Lockwood & Co.
Adelaide Winkman · (2 episodes)
2023

Woodlands Dark and Days Bewitched: A History of Folk Horror
Self
2021

Paul Dood’s Deadly Lunch Break
Kath
2021

Verisimilitude
Casting Director
2020

Days of the Bagnold Summer
Carol
2020

Hitmen
Kirsty (voice) · (1 episode)
2020
Innocence
2019

Dark Encounter
Arlene Burroughs
2019

Sometimes Always Never
Sue
2019

Get Duked!
Superintendent
2019

Black Mirror: Bandersnatch
Dr. Haynes
2018

Salt
Mother
2018

Hang Ups
Celia Cain · (1 episode)
2018

Solis
Commander Roberts
2018

Flowers
Paula · (1 episode)
2016

Solitudo
Nun
2014

Inside No. 9
Amanda · (1 episode)
2014

The Field
Sylvia
2013

The Last Summer on Earth
Sherry-Ann
2013

Come Fly with Me
Young Mum · (1 episode)
2010

Sherlock
Tessa · (1 episode)
2010

This Is Jinsy
Soosan Noop · (16 episodes)
2010

Horrible Histories
Various · (5 episodes)
2009

Horrible Histories
(20 episodes)
2009

Beehive
(5 episodes)
2008

Beautiful People
Stacey Bile · (1 episode)
2008

Angelo's
Alicia · (6 episodes)
2007

Skins
Jemima · (1 episode)
2007

Man to Man with Dean Learner
(1 episode)
2006

Snuff Box
David Bowie · (1 episode)
2006

The IT Crowd
Patricia · (1 episode)
2006

My Life in Film
Beth · (6 episodes)
2004

The Mighty Boosh
Monkey · (1 episode)
2004

Garth Marenghi's Darkplace
Madeleine Wool / Liz Asher · (6 episodes)
2004

Black Books
Solicitor · (1 episode)
2000