Karen Allen

Katy Schoenstein

Kevin Bacon

Rev. Chip Diller (voice)

Verna Bloom

Marion Wormer

DeWayne Jessie

Otis Day

Stephen Furst

Kent 'Flounder' Dorfman

Henry Herzog

Otis Schoenstein

Tim Matheson

Dr. Eric 'Otter' Stratton, OB/GYN

Bruce McGill

Daniel Simpson 'D-Day' Day

Chris Miller

Curtis Wayne 'Hardbar' Fuller

Peter Riegert

Donald 'Boon' Schoenstein

Martha Smith

Barbara 'Babs' Jensen

John Vernon

Vernon Wormer

James Widdoes

Assistant DA Robert Hoover

John Landis

Self (voice)

Jennifer Freeman

Otter's Patient