Ryan Reynolds

Wade Wilson / Deadpool / Nicepool

Hugh Jackman

Logan / Wolverine

Emma Corrin

Cassandra Nova

Matthew Macfadyen

Mr. Paradox

Dafne Keen

Laura / X-23

Jon Favreau

Happy Hogan

Morena Baccarin

Vanessa

Rob Delaney

Peter

Leslie Uggams

Blind Al

Jennifer Garner

Elektra

Wesley Snipes

Blade

Channing Tatum

Gambit

Chris Evans

Johnny Storm

Henry Cavill

The Cavillrine

Wunmi Mosaku

B-15

Aaron Stanford

Pyro

Tyler Mane

Sabretooth

Karan Soni

Dopinder

Brianna Hildebrand

Negasonic Teenage Warhead

Shioli Kutsuna

Yukio

Stefan Kapičić

Colossus (voice)

Randal Reeder

Buck

Lewis Tan

Shatterstar

Nick Pauley

Dancepool

Sonita Henry

Mrs. Chipman

Ryan McKen

Mr. Chipman

Nanak Phlora

Elliot Chipman

Aydin Ahmed

Kevin Chipman

Leemore Marrett Jr.

Minuteman Leader

James Dryden

TVA Tech

Ollie Palmer

Bar Patron

Greg Hemphill

Seedy Bartender

Aaron W Reed

Juggernaut

Mike Waters

Blob

Rob McElhenney

TVA Soldier

James Reynolds

Screaming Mutant (voice)

Ed Kear

Outpost Tech

Paul G. Raymond

TVA Office Agent

Blake Lively

Ladypool (voice)

Inez Reynolds

Kidpool (voice)

Nathan Fillion

Headpool (voice)

Matthew McConaughey

Cowboypool (voice)

OIin Reynolds

Babypool (voice)

Paul Mullin

Welshpool

Alex Kyshkovych

Canadapool

Chris Hemsworth

Thor Odinson (archive footage) (uncredited)

Billy Clements

Russian (uncredited)

Daniel Medina Ramos

Toad (uncredited)

Jade Lye

Lady Deathstrike (uncredited)

Nilly Cetin

Quill (uncredited)

Eduardo Gago Muñoz

Azazel (uncredited)

Chloe Kibble

Callisto (uncredited)

Curtis Rowland Small

Bullseye (uncredited)

Ayesha Hussain

Psylocke (uncredited)

Jessica Walker

Arclight (uncredited)

Harry Holland

Haroldpool (uncredited)

Kevin Fortin

Zenpool (uncredited)