Melissa McCarthy

Detective Connie Edwards

Bill Barretta

Phil Philips / Junkyard / Boar

Leslie David Baker

Lt. Banning

Elizabeth Banks

Jenny

Joel McHale

Agent Campbell

Maya Rudolph

Bubbles

Dorien Davies

Sandra

Drew Massey

Goofer / Vinny

Kevin Clash

Bumblypants / Lyle

Michael McDonald

Ronovan Scargle

Cynthy Wu

Brittenie Marlowe

Mitch Silpa

Tommy

Hemky Madera

Tito

Benjamin Royer

Rick

Brekkan Spens

Dick

Ryan Tran

Phil

Fortune Feimster

Robin

Brian Palermo

Paramedic

Damon Jones

Police Station Guard John / Puppet Doctor

Ryan Gaul

Officer Milligan

Jimmy O. Yang

Officer Delancey

Dennis Keiffer

Junior

Jim Palmer

Caesar

Michael Croner

Jack Cook

Barry Rothbart

Fireman

Steve Mallory

Kerry

Dana Schick

Pretty Girl

Jaye Razor

Razor

Jen Sung

Sandra's Bodyguard

Bryan Cartago

Sandra's Bodyguard

Brett Wagner

Rio

Colleen Smith

Carol / Dalmatian / Cara

Ben Falcone

Donny

Victor Yerrid

Larry / Old Man Puppet

Ted Michaels

Sexist Thug / Ezra

Brian Henson

Crab

Patty Guggenheim

Roxy

Donna Kimball

Roxy / Cow / Rotten Cotton Girl

Alice Dinnean

Rotten Cotton Girl

Allan Trautman

Octopus / Puppet Doctor