Will Ferrell

Megamind (voice)

Tina Fey

Roxanne Ritchi (voice)

Jonah Hill

Hal Stewart / Tighten (voice)

Brad Pitt

Metro Man (voice)

David Cross

Minion (voice)

Justin Theroux

Megaminds's Father (voice)

Ben Stiller

Bernard (voice)

Jessica Schulte

Megamind's Mother (voice)

Tom McGrath

Lord Scott / Prison Guard (voice)

J.K. Simmons

Warden (voice)

Emily Nordwind

Lady Scott (voice)

Quinn Dempsey Stiller

Schoolchild (voice)

Ella Stiller

Schoolchild (voice)

Brian Hopkins

Prisoner (voice)

Christopher Knights

Prison Guard (voice)

Mike Mitchell

Father in Crowd (voice)

Jack Blessing

Newscaster (voice)

Jasper Johannes Andrews

Crying Baby (voice)

Stephen Kearin

Mayor (voice)

Rob Corddry

Metro City Citizen (uncredited)