Keanu Reeves

Bob Arctor

Robert Downey Jr.

James Barris

Woody Harrelson

Ernie Luckman

Winona Ryder

Donna Hawthorne

Rory Cochrane

Charles Freck

Mitch Baker

Brown Bear Lodge Host

Sean Allen

Additional Fred Scramble Suit Voice (voice)

Cliff Haby

Voice from Headquarters (voice)

Steven Chester Prince

Cop

Natasha Valdez

Waitress

Mark Turner

Additional Hank Scramble Suit Voice (voice)

Chamblee Ferguson

Medical Deputy #2

Angela Rawna

Medical Deputy #1

Eliza Stevens

Arctor's Daughter #1

Sarah Menchaca

Arctor's Daughter #2

Melody Chase

Arctor's Wife

Leif Anders

Freck Suicide Narrator (voice)

Turk Pipkin

Creature

Alex Jones

Street Prophet

Lisa Marie Newmyer

Connie

Wilbur Penn

Medical Officer #1

Ken Webster

Medical Officer #2

Hugo Perez

New Path Staff Member #1

Rommel Sulit

New Path Staff Member #2

Dameon Clarke

Mike

Christopher Ryan

New Path Resident #1

Leila Plummer

New Path Resident #2

Jason Douglas

New Path Farm Manager

Marco Perella

Donald

Gary Teague

Brown Bear Lodge Member (uncredited)